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Adhesion protein optimizes border

Feb. 15, 2019, 10:17 AM

The epithelial cells that line the intestines build a specialized cell surface — the “brush border” — that processes and absorbs nutrients, and defends against pathogens. The brush border consists of thousands of finger-like membrane protrusions (microvilli) on each cell.

Matthew Tyska, PhD, and colleagues previously implicated the adhesion protein CDHR2 in the tight packing of microvilli on cultured cells. Now, they have generated mice lacking CDHR2 expression in the intestinal tract to explore the protein’s role in building brush borders in vivo.

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