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RNA processing and antiviral immunity

by Dec. 13, 2018, 10:05 AM

The RIG-I like receptors (RLRs) are intracellular enzyme sentries that detect viral infection and initiate a first line of antiviral defense. The cellular molecules that activate RLRs in vivo are not clear.

John Karijolich, PhD, and colleagues have made the surprising discovery that host-derived RNAs — not viral molecules — activate RLRs. The investigators studied the cellular response to infection with Kaposi’s sarcoma-associated herpesvirus (KSHV), an oncogenic virus and AIDS-associated pathogen that causes Kaposi’s sarcoma and primary effusion lymphoma (PEL).

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