RNA processing and antiviral immunityby Liz Entman Dec. 13, 2018, 10:05 AM
The RIG-I like receptors (RLRs) are intracellular enzyme sentries that detect viral infection and initiate a first line of antiviral defense. The cellular molecules that activate RLRs in vivo are not clear.
John Karijolich, PhD, and colleagues have made the surprising discovery that host-derived RNAs — not viral molecules — activate RLRs. The investigators studied the cellular response to infection with Kaposi’s sarcoma-associated herpesvirus (KSHV), an oncogenic virus and AIDS-associated pathogen that causes Kaposi’s sarcoma and primary effusion lymphoma (PEL).