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Novel genetic study sheds new light on risk of heart attack

by Oct. 11, 2018, 3:01 PM

Loss of a protein that regulates mitochondrial function can greatly increase the risk of myocardial infarction (heart attack), Vanderbilt scientists reported Oct. 3 in the journal eLife.

The study illustrates how “integrative genomics,” a combination of basic research, a human biobank linked to electronic health records and novel computational genetic approaches can identify genetically determined changes in gene expression that contribute to complex diseases.

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