Stretch, inflammation and hypertensionby Liz Entman Oct. 4, 2018, 3:22 PM
Monocytes are known to play an important role in hypertension, although the exact mechanism remains unclear. It is hypothesized that a potential source of monocyte activation originates from its interaction with the vascular endothelium.
In a study of circulating human monocytes and monocytes cultured with human aortic endothelial cells, David Harrison, MD, and colleagues explored the influence of increased vascular endothelial stretch on monocyte phenotype and function during hypertension.
The study published in Cardiovascular Research sheds light on how changes in mechanical forces in the vessel enhance immune cell activation thus promoting hypertension.