A new target for lung cancerby Liz Entman Aug. 17, 2018, 8:31 AM
Recent studies have discovered a role for the transporter protein xCT in the survival of different cancer cell types including breast, glioma and lymphoma. Smoking induces xCT expression in oral cancer cells, suggesting that this protein may also support lung tumor survival and progression.
Xiangming Ji, PhD, Pierre Massion, MD, and colleagues have now studied the role of xCT in non-small cell lung cancer (NSCLC). They demonstrated that xCT was highly expressed at the cell surface in NSCLC tumors and that elevated xCT correlated with advanced stage cancer and worse five-year survival in patients.