Novel insights on “leaky” gutby Liz Entman Jul. 20, 2018, 8:47 AM
Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the small and the large intestine. IBD patients experience bloody diarrhea and abdominal pain and have an increased risk of developing colon cancer.
Disruption of the integrity of the intestinal lining or epithelium contributes to a “leaky” gut and is a common feature of patients with IBD. Tight junctional complexes, highly specialized structures at the apical tip of epithelial cells, are critical to maintaining the epithelial barrier.
Yash Choksi, MD, Christopher Williams, MD, PhD, and colleagues explored the role of a tight junction-associated transmembrane protein, blood vessel epicardial substance (BVES), in mouse models of colitis.