Skip to Content
by Leigh MacMillan | Tuesday, Aug. 19, 2014, 8:00 AM
Eye trauma is the fourth leading cause of blindness globally and is a particular problem in veterans who have experienced blast-induced traumatic brain injury. Tonia Rex, Ph.D., and colleagues are exploring the cellular and molecular responses of the eye to blast injury.
The investigators reported in the August issue of Investigative Ophthalmology & Visual Science that oxidative stress, neuroinflammation and cell death increase over time post-blast, suggesting an ongoing neurodegenerative process. They found that initial outer retinal changes resolved or remained focal, but that inner retinal changes spread from focal regions to the entire retina over time.
The model demonstrates that eye blast trauma causes molecular changes and a decrease in visual acuity within the first month post-blast, despite a lack of obvious eye injury. The response matches the delayed visual deficit in some blast-exposed veterans, suggesting that the mouse model may be valuable for testing new therapeutic options.
Send suggestions for articles to highlight in Aliquots and any other feedback about the column to firstname.lastname@example.org
Leigh MacMillan, (615) 322-4747
Health and Medicine, Reporter, Research Aliquots, blindness, Department of Defense, eye, Investigative Ophthalmology & Visual Science, NEI, NIH, Ophthalmology and Visual Sciences, Reporter Aug 15 2014, Research to Prevent Blindness, Tonia Rex, trauma, traumatic brain injury, Vanderbilt Eye Institute, veterans
There are lots of ways to keep up with Vanderbilt. Choose your preferred method: