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Individuals with Williams syndrome are highly sociable and have little fear of strangers, but they often exhibit significant non-social fears. Abnormal function of the amygdala – a brain region involved in emotional processing – may play a role in these features, but it is unclear whether these abnormalities are specific to WS or are generally associated with traits like sociability and fearfulness.
Using functional MRI, Jennifer Blackford and colleagues measured amygdala response to fear-inducing social and non-social images in WS compared to two control groups – individuals with high levels of non-social fear (inhibited temperament, or IT) and individuals with high sociability (uninhibited temperament, or UT).
They found that the WS group had larger amygdala responses when viewing non-social fear images (e.g., spiders) compared to the IT group. However, their response to fearful social images was proportionate to their sociability. The results, reported in the July Developmental Cognitive Neuroscience, suggest heightened amygdala response to non-social fear is specific to WS.
Melissa Stamm, (615) 322-4747
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