Vanderbilt Center For Structural Biology

Jennifer Doudna, Ph.D., recipient of a 2015 Breakthrough Prize in Life Sciences, will deliver the next Flexner Discovery Lecture on Thursday, Jan. 8. Read More

New structural findings reveal how "gatekeeper" proteins participate in the secretion systems bacteria use to infect host cells. Read More

Insights into the workings of DNA damage response proteins such as SMARCAL1 could suggest new ways to improve genome integrity and prevent cancer. Read More

Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage. Read More

Targeting the enzyme FosB could make antibiotic-resistant staph bacteria sensitive to the antibiotic fosfomycin. Read More

A multidisciplinary study conducted by the combined efforts of Vanderbilt University graduate students has led to the first evidence that abnormal messenger RNA export from the nucleus to the cytoplasm can cause human disease. Read More

Vanderbilt research shows that human antibodies to the natural strain of H5N1 also protected against a dangerous lab-created airborne strain developed several years ago by scientists in the Netherlands and at the University of Wisconsin. Read More

Charles Sanders, Ph.D., professor of Biochemistry, has been selected as a recipient of the 2013 Hans Neurath Award from the Protein Society. He shares the honor with Jennifer Doudna, Ph.D., a Howard Hughes Medical Institute investigator at the University of California, Berkeley. Read More

Vanderbilt investigators report new insights to the workings of calprotectin, an immune system protein that “starves” bacterial pathogens of the metal nutrients they require. Read More

A team led by Vanderbilt University investigators has discovered two new genes — both coding for the signaling protein calmodulin — associated with severe early-onset disorders of heart rhythm. Read More

Structural studies reveal a new framework for understanding a central player in DNA processing. Read More

Understanding how the main receptor for light interacts with other signaling molecules may inform new pharmaceutical development. Read More

It may be possible to fight hospital-acquired pathogens like Acinetobacter baumannii by targeting the bacterium’s need for the nutrient metal zinc. Read More

The molecular structure of a protein involved in Alzheimer’s disease – and the surprising discovery that it binds cholesterol – could lead to new therapeutics for the memory-robbing disease. Read More

The antibiotics of the future could take a page from the immune system’s playbook – and “starve” bacteria of the nutrients they need. Read More

Vanderbilt University’s acquisition of a 900 megahertz nuclear magnetic resonance (NMR) spectrometer will accelerate studies on cancer and Alzheimer’s disease. Read More