Oxidative Stress
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Vanderbilt mourns loss of renowned clinical pharmacologist Jackson Roberts II, MD
Jackson Roberts II, MD, an internationally known clinical pharmacologist in the Vanderbilt University School of Medicine who helped define the role of lipid peroxidation and oxidative stress in human disease, died May 31 in Nashville. He was 79. Read MoreJun 5, 2023
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Mitochondrial stress and hypertension
Oxidative stress and toxic products called isolevuglandins in mitochondria play a role in endothelial dysfunction and hypertension — and getting rid of them with a special “scavenger” molecule has therapeutic potential. Read MoreJan 12, 2021
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The importance of estrogen cycles
Deborah Lannigan and colleagues identify a key regulator of the estrogen receptor and suggest that its downregulation by oral contraceptives may increase oxidative stress and DNA damage, a common cause of cancer. Read MoreAug 6, 2020
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A new contributor to atherosclerosis
Sean Davies and colleagues are exploring lipid aldehydes produced during oxidative stress and their contribution to HDL dysfunction and atherosclerosis. Read MoreJan 27, 2020
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Mitochondrial mutations and disease
New findings suggest that oxidative stress damages mitochondrial DNA, and they link this damage to a disease state. Read MoreFeb 22, 2018
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Bypassing DNA damage
Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage. Read MoreMay 9, 2014
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Oxidative stress in autism
A biomarker for oxidative stress is elevated in patients with both autism spectrum disorder and gastrointestinal dysfunction, suggesting opportunities for individualized approaches to clinical care. Read MoreAug 14, 2013