NIAAA
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Modulating stress circuits
Danny Winder and colleagues have demonstrated how norepinephrine and a stress factor call CRF interact, which may lead to new treatments for stress-related disorders. Read MoreFeb 15, 2019
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Award bolsters study of alcohol’s impact on the brain
Vanderbilt University researcher Danny Winder, Ph.D., has received a MERIT Award from the National Institute of Alcohol Abuse and Addiction (NIAAA), part of the National Institutes of Health, for his contributions to understanding how alcohol affects the brain. Read MoreJul 28, 2016
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COX-2 blocker could help PTSD
COX-2 inhibitors – used clinically to reduce inflammation and pain – may find new applications for treating PTSD and other stress-related psychiatric disorders like major depression. Read MoreMay 12, 2016
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Anti-inflammatory protein “rheostat” sheds light on leaky blood vessels
Vanderbilt researchers have discovered that the protein CRADD counteracts inflammatory injury to endothelial cells, which could assist the development of new therapies for inflammatory vascular disorders. Read MoreAug 1, 2014
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New target for stopping inflammation
Importin alpha 5, a member of a family of proteins that “shuttle” other proteins into the nucleus, is a potential new target for drugs to treat inflammatory diseases. Read MoreOct 11, 2013
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Nuclear shield against cell death
The protein SARM appears to protect cells from inflammation-driven death by stabilizing the nuclear laminin scaffold. Read MoreAug 8, 2013
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Low prenatal alcohol’s brain impact
Even relatively low levels of in utero alcohol exposure impact fetal brain development, and the effects last into adulthood, study finds. Read MoreDec 21, 2012
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Alcohol’s molecular mediators
Therapeutic agents focusing on the brain region involved in stress-induced relapse may be effective in preventing relapse in patients with alcohol use disorders. Read MoreJan 23, 2012