Possible new breast cancer treatment target identified
Two-thirds of breast cancers depend on the female hormone estrogen for growth. Treatment options for those patients include antiestrogen drugs that block tumor cells from growing.
However, many women eventually develop resistance to those antiestrogen therapies and their tumors start growing again. In about 10 percent of those patients, this resistance is caused by high tumor levels of an oncogene called HER2.
The drugs trastuzumab (Herceptin) and lapatinib have been developed for use in those patients. But there is no effective treatment for the rest of the patients who develop resistance to endocrine therapies.
Read more about a promising target for new therapies.
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